Fluanxol Depot may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. It should not be given concomitantly with guanethidine or similarly acting compounds, since neuroleptics may block the antihypertensive effect of these compounds. Fluanxol Depot may lower the effect of adrenergic drugs and concomitant use of metoclopramide and piperazine increases the risk of extrapyramidal symptoms.